| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 20-2-25 18:45 | FK Bodö/Glimt | FC Twente Enschede | 5:2n.v. |
| 20-2-25 18:45 | FCSB Bukarest | PAOK Saloniki | 2:0 |
| 20-2-25 18:45 | Galatasaray Istanbul | AZ Alkmaar | 2:2 |
| 20-2-25 18:45 | AS Rom | FC Porto | 3:2 |
| 20-2-25 21:00 | RSC Anderlecht | Fenerbahce Istanbul | 2:2 |
| 20-2-25 21:00 | Ajax Amsterdam | Royale Union Saint-Gilloise | 1:2n.v. |
| 20-2-25 21:00 | Real Sociedad | FC Midtjylland | 5:2 |
| 20-2-25 21:00 | Viktoria Pilsen | Ferencvárosi TC | 3:0 |